Biology:SprX small RNA
From HandWiki
| SprX sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of SprX small RNA | |
| Identifiers | |
| Rfam | RF02672 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0040033 |
| SO | 0000370 |
| PDB structures | PDBe |
In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.[3]
See also
References
- ↑ "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". Nucleic Acids Research 38 (19): 6620–36. October 2010. doi:10.1093/nar/gkq462. PMID 20511587.
- ↑ "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". Nucleic Acids Research 42 (8): 4892–905. April 2014. doi:10.1093/nar/gku149. PMID 24557948.
- ↑ "Enhancement of the pathogenicity of Staphylococcus aureus strain Newman by a small noncoding RNA SprX1". Medical Microbiology and Immunology 205 (6): 563–574. December 2016. doi:10.1007/s00430-016-0467-9. PMID 27438010.
 |  |
