Biology:Strabismus (protein)
| vang-like 1 (van gogh, Drosophila) | |
|---|---|
| Identifiers | |
| Symbol | VANGL1 |
| NCBI gene | 81839 |
| OMIM | 610132 |
Strabismus was originally identified as a Drosophila protein involved in planar cell polarity.[1] Flies with mutated strabismus genes have altered development of ommatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh").
The amino acid sequence and localization studies for Strabismus indicate that it is a membrane protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus.[2] In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells.[3]
Vertebrate cell movement
| vang-like 2 (van gogh, Drosophila) | |
|---|---|
| Identifiers | |
| Symbol | VANGL2 |
| NCBI gene | 57216 |
| OMIM | 600533 |
VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis.[4]
Humans
In humans, mutations in VANGL1 have been associated with neural tube defects including spina bifida,[5] and with some forms of cancer including hepatocellular carcinoma.[6][7]
References
- ↑ "Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila". Development 125 (6): 1149–59. March 1998. PMID 9463361. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=9463361.
- ↑ "Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning". Development 130 (13): 3007–14. July 2003. doi:10.1242/dev.00526. PMID 12756182. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=12756182.
- ↑ "Planar polarity from flies to vertebrates". J. Cell Sci. 117 (Pt 4): 527–33. February 2004. doi:10.1242/jcs.00973. PMID 14730010. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=14730010.
- ↑ "The planar polarity gene strabismus regulates convergent extension movements in Xenopus". EMBO J. 21 (5): 976–85. March 2002. doi:10.1093/emboj/21.5.976. PMID 11867525.
- ↑ "Mutations in VANGL1 associated with neural-tube defects.". N. Engl. J. Med. 356 (14): 1432–7. 2007. doi:10.1056/NEJMoa060651. PMID 17409324. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17409324.
- ↑ "Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma.". Int. J. Oncol. 20 (6): 1173–8. 2002. doi:10.3892/ijo.20.6.1173. PMID 12011995.
- ↑ Katoh M (2002). "Strabismus (STB)/Vang-like (VANGL) gene family". Int. J. Mol. Med. 10 (1): 11–5. doi:10.3892/ijmm.10.1.11. PMID 12060845.
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