Biology:TFDP1

Generic protein structure example

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]

Interactions

TFDP1 has been shown to interact with:

• E2F1,
• E2F5, and
• P53.

Further reading

• "In vivo association of E2F and DP family proteins.". Mol. Cell. Biol. 15 (5): 2536–46. 1995. doi:10.1128/mcb.15.5.2536. PMID 7739537. 
• "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. 1995. doi:10.1128/mcb.15.6.3082. PMID 7760804. 
• "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. 1995. doi:10.1073/pnas.92.6.2403. PMID 7892279. Bibcode: 1995PNAS...92.2403S. 
• "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev. 8 (22): 2665–79. 1994. doi:10.1101/gad.8.22.2665. PMID 7958924. 
• "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90. 1994. doi:10.1101/gad.8.22.2680. PMID 7958925. 
• "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.". EMBO J. 13 (13): 3104–14. 1994. doi:10.1002/j.1460-2075.1994.tb06609.x. PMID 8039504. 
• "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.". Genes Dev. 7 (10): 1850–61. 1993. doi:10.1101/gad.7.10.1850. PMID 8405995. 
• "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. 1996. doi:10.1073/pnas.93.15.7594. PMID 8755520. Bibcode: 1996PNAS...93.7594R. 
• "Functional interaction between DP-1 and p53.". Mol. Cell. Biol. 16 (10): 5888–95. 1996. doi:10.1128/mcb.16.10.5888. PMID 8816502. 
• "Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10321–6. 1996. doi:10.1073/pnas.93.19.10321. PMID 8816798. Bibcode: 1996PNAS...9310321V. 
• "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.". J. Cell Sci.. 109 ( Pt 7) (7): 1717–26. 1997. doi:10.1242/jcs.109.7.1717. PMID 8832394. 
• "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.". Genes Dev. 10 (7): 851–61. 1996. doi:10.1101/gad.10.7.851. PMID 8846921. 
• "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. 1998. doi:10.1073/pnas.95.6.2850. PMID 9501179. Bibcode: 1998PNAS...95.2850T. 
• "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.". Oncogene 17 (5): 611–23. 1998. doi:10.1038/sj.onc.1201975. PMID 9704927. 
• "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.". Mol. Cell. Biol. 19 (4): 2936–45. 1999. doi:10.1128/mcb.19.4.2936. PMID 10082561. 
• "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors.". Eur. J. Immunol. 29 (10): 3380–9. 1999. doi:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID 10540350. 
• "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.". Oncogene 19 (43): 5000–9. 2000. doi:10.1038/sj.onc.1203843. PMID 11042687. 
• "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.". EMBO J. 20 (9): 2273–85. 2001. doi:10.1093/emboj/20.9.2273. PMID 11331592.