Biology:E2F5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.

Interactions

E2F5 has been shown to interact with TFDP1.

See also

• E2F

Further reading

• "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology 15 (6): 3082–9. Jun 1995. doi:10.1128/mcb.15.6.3082. PMID 7760804. 
• "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes & Development 8 (22): 2665–79. Nov 1994. doi:10.1101/gad.8.22.2665. PMID 7958924. 
• "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo". Genes & Development 8 (22): 2680–90. Nov 1994. doi:10.1101/gad.8.22.2680. PMID 7958925. 
• "Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors". Cellular & Molecular Biology Research 41 (3): 147–54. 1996. PMID 8589754. 
• "The subcellular localization of E2F-4 is cell-cycle dependent". Proceedings of the National Academy of Sciences of the United States of America 94 (10): 5095–100. May 1997. doi:10.1073/pnas.94.10.5095. PMID 9144196. Bibcode: 1997PNAS...94.5095L. 
• "The molecular and functional characterization of E2F-5 transcription factor". Biochemical and Biophysical Research Communications 242 (3): 586–92. Jan 1998. doi:10.1006/bbrc.1997.8010. PMID 9464260. 
• "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators". Nature Cell Biology 2 (4): 232–9. Apr 2000. doi:10.1038/35008660. PMID 10783242. 
• "E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control". Molecular Cell 6 (3): 729–35. Sep 2000. doi:10.1016/S1097-2765(00)00071-X. PMID 11030352. 
• "Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation". The Journal of Biological Chemistry 276 (26): 23531–8. Jun 2001. doi:10.1074/jbc.M100780200. PMID 11319226. 
• "Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism". Molecular and Cellular Biology 22 (2): 453–68. Jan 2002. doi:10.1128/MCB.22.2.453-468.2002. PMID 11756542. 
• "Active nuclear import and export pathways regulate E2F-5 subcellular localization". The Journal of Biological Chemistry 277 (37): 34471–9. Sep 2002. doi:10.1074/jbc.M205827200. PMID 12089160. 
• "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell 110 (1): 19–32. Jul 2002. doi:10.1016/S0092-8674(02)00801-2. PMID 12150994. 
• "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer". Oncogene 22 (23): 3511–7. Jun 2003. doi:10.1038/sj.onc.1206578. PMID 12789259. 
• "Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5". The Journal of Cell Biology 162 (2): 173–83. Jul 2003. doi:10.1083/jcb.200302085. PMID 12860972. 
• "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197. 
• "Aberrant regulation of survivin by the RB/E2F family of proteins". The Journal of Biological Chemistry 279 (39): 40511–20. Sep 2004. doi:10.1074/jbc.M404496200. PMID 15271987. 
• "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556. 
• "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene 24 (13): 2204–17. Mar 2005. doi:10.1038/sj.onc.1208206. PMID 15735762. 
• "Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development". The International Journal of Developmental Biology 49 (7): 859–65. 2006. doi:10.1387/ijdb.051996as. PMID 16172982. 

External links

• E2F5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.