Biology:TIMM13
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.[1][2][3]
Function
This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.[3]
Interactions
TIMM13 has been shown to interact with TIMM8A.[4][5]
References
- ↑ "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics 61 (3): 259–67. Nov 1999. doi:10.1006/geno.1999.5966. PMID 10552927.
- ↑ "Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space". Molecular Biology and Evolution 24 (5): 1149–60. May 2007. doi:10.1093/molbev/msm031. PMID 17329230.
- ↑ 3.0 3.1 "Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=26517.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1). 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics 11 (5): 477–86. Mar 2002. doi:10.1093/hmg/11.5.477. PMID 11875042.
Further reading
- "The mitochondrial import machinery for preproteins". Critical Reviews in Biochemistry and Molecular Biology 36 (3): 291–336. 2001. doi:10.1080/20014091074200. PMID 11450972.
- "Protein import into mitochondria". IUBMB Life 52 (3–5): 101–12. 2002. doi:10.1080/15216540152845894. PMID 11798021.
- "The protein import motor of mitochondria". Nature Reviews. Molecular Cell Biology 3 (8): 555–65. Aug 2002. doi:10.1038/nrm878. PMID 12154367.
- "Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1592 (1): 25–34. Sep 2002. doi:10.1016/S0167-4889(02)00261-6. PMID 12191765.
- "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Letters 464 (1–2): 41–7. Dec 1999. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. Bibcode: 1999FEBSL.464...41B.
- "The role of the TIM8-13 complex in the import of Tim23 into mitochondria". The EMBO Journal 19 (23): 6392–400. Dec 2000. doi:10.1093/emboj/19.23.6392. PMID 11101512.
- "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". The Journal of Biological Chemistry 276 (40): 37327–34. Oct 2001. doi:10.1074/jbc.M105313200. PMID 11489896.
- "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics 11 (5): 477–86. Mar 2002. doi:10.1093/hmg/11.5.477. PMID 11875042.
- "How mitochondria import hydrophilic and hydrophobic proteins". Trends in Cell Biology 12 (7): 299–303. Jul 2002. doi:10.1016/S0962-8924(02)02310-3. PMID 12185844.
- "The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins". The Journal of Cell Biology 158 (6): 1017–27. Sep 2002. doi:10.1083/jcb.200205124. PMID 12221072.
- "The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics 13 (18): 2101–11. Sep 2004. doi:10.1093/hmg/ddh217. PMID 15254020.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1). 2007. doi:10.1038/msb4100134. PMID 17353931.
 |  |
