Biology:TONSL

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Tonsoku-like, DNA repair protein is a protein that in humans is encoded by the TONSL gene.

Function

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.

Further reading

• "Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply". The EMBO Journal 31 (8): 2013–23. April 2012. doi:10.1038/emboj.2012.55. PMID 22407294. 
• "Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2)". Annals of Human Genetics 64 (Pt 1): 15–23. January 2000. doi:10.1046/j.1469-1809.2000.6410015.x. PMID 11246458. 
• "Identification of the MMS22L-TONSL complex that promotes homologous recombination". Molecular Cell 40 (4): 632–44. November 2010. doi:10.1016/j.molcel.2010.10.023. PMID 21055984. 
• "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability". Molecular Cell 40 (4): 645–57. November 2010. doi:10.1016/j.molcel.2010.10.022. PMID 21055985. 
• "The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination". Molecular Cell 40 (4): 619–31. November 2010. doi:10.1016/j.molcel.2010.10.024. PMID 21055983. 
• "Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study". Critical Care 14 (6): R227. 2010. doi:10.1186/cc9377. PMID 21171993. 
• "Cloning of a differentially expressed I kappa B-related protein". The Journal of Biological Chemistry 270 (18): 10680–5. May 1995. doi:10.1074/jbc.270.18.10680. PMID 7738005. 
• "RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells". The EMBO Journal 29 (24): 4210–22. December 2010. doi:10.1038/emboj.2010.304. PMID 21113133. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.