Biology:TOPORS
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E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.[1][2][3][4]
References
- ↑ "Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein". Nucleic Acids Res 27 (12): 2538–44. Jul 1999. doi:10.1093/nar/27.12.2538. PMID 10352183.
- ↑ "The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies". Exp Cell Res 277 (2): 152–60. Jun 2002. doi:10.1006/excr.2002.5550. PMID 12083797.
- ↑ "Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy". Am J Hum Genet 81 (5): 1098–103. Oct 2007. doi:10.1086/521953. PMID 17924349.
- ↑ "Entrez Gene: TOPORS topoisomerase I binding, arginine/serine-rich". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10210.
Further reading
- "Identification of a novel gene encoding a p53-associated protein.". Gene 235 (1–2): 93–101. 1999. doi:10.1016/S0378-1119(99)00203-6. PMID 10415337.
- "IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process". Arthritis Res. 2 (4): 303–14. 2001. doi:10.1186/ar105. PMID 11056671.
- "Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence". J. Biol. Chem. 276 (17): 14004–13. 2001. doi:10.1074/jbc.M010262200. PMID 11278651. https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/150162/1/yigak02391.pdf.
- "Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression". J. Gen. Virol. 83 (Pt 3): 511–6. 2002. doi:10.1099/0022-1317-83-3-511. PMID 11842245.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. 2003. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
- "The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation". Exp. Cell Res. 290 (1): 13–27. 2003. doi:10.1016/S0014-4827(03)00292-1. PMID 14516784.
- "The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor". Oncogene 23 (31): 5293–300. 2004. doi:10.1038/sj.onc.1207700. PMID 15107820.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53". J. Biol. Chem. 279 (35): 36440–4. 2004. doi:10.1074/jbc.C400300200. PMID 15247280.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer". Lung Cancer 46 (1): 21–8. 2005. doi:10.1016/j.lungcan.2004.03.009. PMID 15364129.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons". J. Biol. Chem. 280 (14): 14349–55. 2005. doi:10.1074/jbc.M411890200. PMID 15699047.
- "topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage". Oncogene 24 (21): 3385–96. 2005. doi:10.1038/sj.onc.1208554. PMID 15735665.
- "Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo". FEBS Lett. 579 (22): 5007–12. 2005. doi:10.1016/j.febslet.2005.07.088. PMID 16122737.
- "A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p". Hum. Genet. 118 (3–4): 501–3. 2006. doi:10.1007/s00439-005-0063-3. PMID 16189705.
External links
- TOPORS human gene location in the UCSC Genome Browser.
- TOPORS human gene details in the UCSC Genome Browser.
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