Biology:Telomeric repeat-containing RNAs

From HandWiki

Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA that forms integral part of telomeric heterochromatin along with the telomeric binding proteins.[1] [2] It plays a key role in maintaining the telomeric structure and plays an important role during the processes like cell differentiation and development. TERRAs are transcribed from the telomeric end of the DNA and almost all the DNA ends have been shown to transcribe the molecule.[3]

Biogenesis of TERRA

TERRA consists of both telomeric and subtelomeric regions. The transcription is initiated in subtelomeric regions and proceeds in the centromere to telomere direction. TERRA is ubiquitously expressed in most all of the tissues by almost all of the mammals studied. TERRA is also expressed in yeasts.

Several studies have shown that TERRA is primarily transcribed by RNA polymerase II, though RNA polymerase I and RNA polymerase III could also play some part in biogenesis.[4]

References

  1. ↑ López de Silanes, Isabel; d'Alcontres, Martina Stagno; Blasco, Maria A (29 June 2010). "TERRA transcripts are bound by a complex array of RNA-binding proteins". Nature Communications 1 (3): 1–9. doi:10.1038/ncomms1032. PMID 20975687. http://www.nature.com/ncomms/journal/v1/n3/full/ncomms1032.html. 
  2. ↑ Luke B1, Lingner J (2009). "TERRA: telomeric repeat-containing RNA". The EMBO Journal 28 (17): 2503–2510. doi:10.1038/emboj.2009.166. PMID 19629047. 
  3. ↑ Blasco, María A. (April 2007). "The epigenetic regulation of mammalian telomeres". Nature Reviews Genetics 8 (4): 299–309. doi:10.1038/nrg2047. http://www.nature.com/nrg/journal/v8/n4/full/nrg2047.html. 
  4. ↑ López de Silanes, Isabel; Graña, Osvaldo; De Bonis, Maria Luigia; Dominguez, Orlando; Pisano, David G.; Blasco, Maria A. (2014). "Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes" (in en). Nature Communications 5: 4723. doi:10.1038/ncomms5723. PMID 25182072. PMC 4164772. http://www.nature.com/ncomms/2014/140903/ncomms5723/abs/ncomms5723.html. 




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