Biology:Thyroid-hormone transaminase
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Thyroid-hormone transaminase | |||||||||
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Identifiers | |||||||||
EC number | 2.6.1.26 | ||||||||
CAS number | 51004-29-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a thyroid-hormone transaminase (EC 2.6.1.26) is an enzyme that catalyzes the chemical reaction
- L-3,5,3'-triiodothyronine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
Thus, the two substrates of this enzyme are L-3,5,3'-triiodothyronine and 2-oxoglutarate, whereas its two products are 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It employs one cofactor, pyridoxal phosphate.
References
Original source: https://en.wikipedia.org/wiki/Thyroid-hormone transaminase.
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