Biology:Tulane virus
| Tulane virus | |
|---|---|
Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Picornavirales |
| Family: | Caliciviridae |
| Genus: | Recovirus |
| Species: | Recovirus tulani
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| Synonyms[1] | |
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Tulane virus (Recovirus tulani) is a calicivirus isolated from the rhesus monkey.[2] It is the sole member of the Recovirus genus.[3] It is a non-enveloped, positive-sense, single-stranded RNA virus, and its genome, which is approximately 6.7 kilobases in length, is reported shortest among the members of the family Caliciviridae . The genome is organized into three open reading frames (ORFs): ORF1 encodes a nonstructural polyprotein involved in viral replication, ORF2 endcodes the major capsid protein (VP1), and ORF3 encodes a basic minor structural protein (VP2)[4].
The virus was first identified in 2008 after being isolated from the stool samples of captive juvenile rhesus macaques (Macaca mulatta) housed at the Tulane National Primate Research Center[4]. It propagates easily in cell lines such as LLC-MK2[5], and recognizes histo-blood group antigens (HBGAs) similar to human noroviruses (HuNoVs)[6]. These features make it a good surrogate candidate for HuNoV studies.
References
- ↑ "History of the taxon: Species: Recovirus tulani (2024 Release, MSL #40)". International Committee on Taxonomy of Viruses. https://ictv.global/taxonomy/taxondetails?taxnode_id=202406501&taxon_name=Recovirus%20tulani.
- ↑ Farkas, Tibor (1 July 2015). "Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis". Journal of General Virology 96 (7): 1504–1514. doi:10.1099/jgv.0.000020. PMID 25502652.
- ↑ "Genus: Recovirus - Caliciviridae - Positive-sense RNA Viruses" (in en). https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/caliciviridae/1168/genus-recovirus. Retrieved 3 September 2020.
- ↑ 4.0 4.1 Farkas, Tibor; Sestak, Karol; Wei, Chao; Jiang, Xi (June 2008). "Characterization of a Rhesus Monkey Calicivirus Representing a New Genus of Caliciviridae". Journal of Virology 82 (11): 5408–5416. doi:10.1128/jvi.00070-08. https://journals.asm.org/doi/10.1128/jvi.00070-08.
- ↑ Chhabra, Preeti; Ranjan, Priya; Cromeans, Theresa; Sambhara, Suryaprakash; Vinjé, Jan (2017-05-01). "Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection" (in en). Journal of General Virology 98 (5): 1016–1026. doi:10.1099/jgv.0.000769. ISSN 0022-1317. PMID 28530548. PMC 5916764. https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000769.
- ↑ Zhang, Dongsheng; Huang, Pengwei; Zou, Lu; Lowary, Todd L.; Tan, Ming; Jiang, Xi (2014-01-02). "Tulane Virus Recognizes the A Type 3 and B Histo-Blood Group Antigens". Journal of Virology 89 (2): 1419–1427. doi:10.1128/jvi.02595-14. https://journals.asm.org/doi/10.1128/jvi.02595-14.
Wikidata ☰ Q28407272 entry
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