Biology:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase
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| UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.91 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase (EC 2.6.1.91, pglE (gene)) is an enzyme with systematic name UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine:2-oxoglutarate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + L-glutamate
This enzyme is a pyridoxal-phosphate protein.
References
- ↑ "In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system". Biochemistry 45 (45): 13659–69. November 2006. doi:10.1021/bi061456h. PMID 17087520.
- ↑ "Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways". The Journal of Biological Chemistry 281 (2): 723–32. January 2006. doi:10.1074/jbc.m511021200. PMID 16286454.
- ↑ "Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni". Biochemistry 47 (7): 1827–36. February 2008. doi:10.1021/bi702032r. PMID 18198901.
- ↑ "Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine". Biochemistry 50 (22): 4936–48. June 2011. doi:10.1021/bi2003372. PMID 21542610.
External links
- UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
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