Biology:UDP-4-amino-4-deoxy-L-arabinose aminotransferase

From HandWiki
UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Identifiers
EC number2.6.1.87
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

UDP-4-amino-4-deoxy-L-arabinose aminotransferase (EC 2.6.1.87, UDP-(beta-L-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase, UDP-Ara4O aminotransferase, UDP-L-Ara4N transaminase) is an enzyme with systematic name UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate

This protein is a pyridoxal 5'-phosphate enzyme.

References

  1. "Origin of lipid A species modified with 4-amino-4-deoxy-L-arabinose in polymyxin-resistant mutants of Escherichia coli. An aminotransferase (ArnB) that generates UDP-4-deoxyl-L-arabinose". The Journal of Biological Chemistry 278 (27): 24731–9. July 2003. doi:10.1074/jbc.m304043200. PMID 12704196. 
  2. "Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme". Structure 10 (11): 1569–80. November 2002. doi:10.1016/s0969-2126(02)00879-1. PMID 12429098. 

External links