Biology:UHRF2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.

Further reading

• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.". Oncogene 23 (46): 7601–10. 2004. doi:10.1038/sj.onc.1208053. PMID 15361834. 
• "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "NIRF induces G1 arrest and associates with Cdk2.". Biochem. Biophys. Res. Commun. 319 (2): 464–8. 2004. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429. 
• "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H. 
• "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.". FEBS Lett. 557 (1–3): 209–14. 2004. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.