Biology:USP25

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Ubiquitin specific peptidase 25 is a protein that in humans is encoded by the USP25 gene.

Function

Ubiquitin is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008].

Further reading

• "Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25". Genome Biol. 2 (10). 2001. doi:10.1186/gb-2001-2-10-research0043. PMID 11597335. 
• "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer 47 (9): 810–8. 2008. doi:10.1002/gcc.20582. PMID 18523997. 
• "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25". Mol. Cell 30 (5): 610–9. 2008. doi:10.1016/j.molcel.2008.03.021. PMID 18538659. 
• "The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition". PLOS ONE 4 (5). 2009. doi:10.1371/journal.pone.0005571. PMID 19440361. Bibcode: 2009PLoSO...4.5571D. 
• "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflamm. Bowel Dis. 16 (6): 907–9. 2010. doi:10.1002/ibd.21105. PMID 19760754. 
• "Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase". Exp. Cell Res. 316 (4): 667–75. 2010. doi:10.1016/j.yexcr.2009.10.023. PMID 19909739. 
• "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. 2010. doi:10.2119/molmed.2009.00159. PMID 20379614. 
• "PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications". Cell Biochem. Biophys. 60 (1–2): 21–38. 2011. doi:10.1007/s12013-011-9176-6. PMID 21480003. 
• "Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation". PLOS ONE 7 (5). 2012. doi:10.1371/journal.pone.0036542. PMID 22590560. Bibcode: 2012PLoSO...736542B. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.