Biology:USP26
USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.[1] The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome.[2] The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.[3]
Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,[1][4] specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).[5]
See also
References
- ↑ 1.0 1.1 "Possible role of USP26 in patients with severely impaired spermatogenesis". European Journal of Human Genetics 13 (3): 336–40. March 2005. doi:10.1038/sj.ejhg.5201335. PMID 15562280.
- ↑ "The impacts of nineteen mutations on the enzymatic activity of USP26". Gene 641: 292–296. January 2018. doi:10.1016/j.gene.2017.10.074. PMID 29111204.
- ↑ Lahav-Baratz, Shirly; Kravtsova-Ivantsiv, Yelena; Golan, Shay; Ciechanover, Aaron (January 2017). "The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2". Biochemical and Biophysical Research Communications 482 (1): 106–111. doi:10.1016/j.bbrc.2016.10.135. ISSN 0006-291X. PMID 27810359. Bibcode: 2017BBRC..482..106L.
- ↑ "Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility". Asian Journal of Andrology 9 (6): 809–14. November 2007. doi:10.1111/j.1745-7262.2007.00305.x. PMID 17968467.
- ↑ "Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26". Molecular Human Reproduction 12 (10): 643–6. October 2006. doi:10.1093/molehr/gal063. PMID 16888075.
External links
- USP26+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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