Biology:UbiD protein domain
In molecular biology this protein domain, refers to UbiD, which is found in prokaryotes, archaea and fungi, with two members in Archaeoglobus fulgidus. They are related to UbiD, a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli that is involved in ubiquinone biosynthesis.[1] The member from Helicobacter pylori has a C-terminal extension of just over 100 residues that is shared, in part, by the Aquifex aeolicus homologue.
Function
Ubiquinone is an essential electron carrier in prokaryotes. In Escherichia coli, the Ubiquinone biosynthesis pathway involves at least nine reactions whereby 3-octaprenyl4-hydroxybenzoate decarboxylase (UbiD) is an enzyme on the pathway which catalyses the conversion of the substrate 3-octaprenyl-4-hydroxybenzoate to the product, 2-octaprenyl phenol.[2] E. coli ubiD- mutants have defects in Q8 biosynthesis, accumulate 4-hydroxy-3-octaprenylbenzoicacid (HP8B), and lack decarboxylase activity in vitro. However, E. coli ubiD- mutants retained the ability to produce about 20–25% of the normal levels of Q 4-hydroxy-3-octaprenylbenzoic acid.[3] In essence, the protein domain, UbiD, is vital to creating ubiquinone, an essential electron carrier in the creation on energy.
References
- ↑ "Identification of the ubiD gene on the Escherichia coli chromosome". J. Bacteriol. 182 (21): 6243–6. November 2000. doi:10.1128/jb.182.21.6243-6246.2000. PMID 11029449.
- ↑ "Ubiquinone (coenzyme Q) biosynthesis in Chlamydophila pneumoniae AR39: identification of the ubiD gene.". Acta Biochim Biophys Sin (Shanghai) 38 (10): 725–30. 2006. doi:10.1111/j.1745-7270.2006.00214.x. PMID 17033719.
- ↑ "The role of UbiX in Escherichia coli coenzyme Q biosynthesis.". Arch Biochem Biophys 467 (2): 144–53. 2007. doi:10.1016/j.abb.2007.08.009. PMID 17889824.
![]() | Original source: https://en.wikipedia.org/wiki/UbiD protein domain.
Read more |