Biology:VARS
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.[1][2]
Function
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.[2]
See also
- Valine-tRNA ligase
References
- ↑ "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry 44 (12): 4805–16. March 2005. doi:10.1021/bi047527z. PMID 15779907.
- ↑ 2.0 2.1 "Entrez Gene: VARS valyl-tRNA synthetase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7407.
Further reading
- "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase". The Biochemical Journal 278 (3): 809–16. September 1991. doi:10.1042/bj2780809. PMID 1898367.
- "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region". The EMBO Journal 8 (8): 2305–12. August 1989. doi:10.1002/j.1460-2075.1989.tb08357.x. PMID 2477242.
- "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry 264 (35): 21131–7. December 1989. doi:10.1016/S0021-9258(19)30056-0. PMID 2556394.
- "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters 238 (2): 262–4. October 1988. doi:10.1016/0014-5793(88)80492-7. PMID 3169261.
- "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry 269 (3): 2086–92. January 1994. doi:10.1016/S0021-9258(17)42139-9. PMID 8294461.
- "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase". Gene 123 (2): 181–6. January 1993. doi:10.1016/0378-1119(93)90122-J. PMID 8428657.
- "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences". Gene 170 (2): 289–91. May 1996. doi:10.1016/0378-1119(96)84699-3. PMID 8666263.
- "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research 13 (12): 2621–36. December 2003. doi:10.1101/gr.1736803. PMID 14656967.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. February 2004. doi:10.1038/ncb1086. PMID 14743216.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit". FEBS Letters 579 (27): 6049–54. November 2005. doi:10.1016/j.febslet.2005.09.062. PMID 16229838.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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