Biology:WDR5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.[1][2]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[2]
Interactions
WDR5 has been shown to interact with Host cell factor C1[3][4] and MLL.[3] It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.[5][6] WDR5 is a key determinant for MYC recruitment to chromatin[7]
References
- ↑ "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". J Biol Chem 276 (49): 46515–22. Dec 2001. doi:10.1074/jbc.M105757200. PMID 11551928.
- ↑ 2.0 2.1 "Entrez Gene: WDR5 WD repeat domain 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11091.
- ↑ 3.0 3.1 Yokoyama, Akihiko; Wang Zhong; Wysocka Joanna; Sanyal Mrinmoy; Aufiero Deborah J; Kitabayashi Issay; Herr Winship; Cleary Michael L (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMID 15199122.
- ↑ Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMID 12670868.
- ↑ Wells, Alexandria C.; Pobezinskaya, Elena L.; Pobezinsky, Leonid A. (April 2020). "Non-coding RNAs in CD8 T cell biology". Molecular Immunology 120: 67–73. doi:10.1016/j.molimm.2020.01.023. ISSN 1872-9142. PMID 32085976.
- ↑ "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.". Nature 472 (7341): 120–4. 2011. doi:10.1038/nature09819. PMID 21423168. Bibcode: 2011Natur.472..120W.
- ↑ Thomas, L. R.; Tansey, W. P. (2015). "Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC". Molecular Cell 58 (3): 1–13. doi:10.1016/j.molcel.2015.02.028. PMID 25818646.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.". Genes Dev. 17 (7): 896–911. 2003. doi:10.1101/gad.252103. PMID 12670868.
- "BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro.". Endocrinology 145 (3): 1050–4. 2004. doi:10.1210/en.2003-1314. PMID 14657013.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.". Mol. Cell. Biol. 24 (13): 5639–49. 2004. doi:10.1128/MCB.24.13.5639-5649.2004. PMID 15199122.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.". Cell 121 (6): 859–72. 2005. doi:10.1016/j.cell.2005.03.036. PMID 15960974.
- "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.". Cell 121 (6): 873–85. 2005. doi:10.1016/j.cell.2005.04.031. PMID 15960975.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo.". Journal of Musculoskeletal & Neuronal Interactions 5 (4): 338–9. 2006. PMID 16340128.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.". Nat. Struct. Mol. Biol. 13 (8): 704–12. 2006. doi:10.1038/nsmb1119. PMID 16829959.
- "Molecular recognition of histone H3 by the WD40 protein WDR5.". Nat. Struct. Mol. Biol. 13 (8): 698–703. 2006. doi:10.1038/nsmb1116. PMID 16829960.
- "Regulation of MLL1 H3K4 methyltransferase activity by its core components.". Nat. Struct. Mol. Biol. 13 (8): 713–9. 2006. doi:10.1038/nsmb1128. PMID 16878130.
- "Structural basis for molecular recognition and presentation of histone H3 by WDR5.". EMBO J. 25 (18): 4245–52. 2006. doi:10.1038/sj.emboj.7601316. PMID 16946699.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "WDR5 is a conserved regulator of protein synthesis gene expression.". Nucleic Acids Research 48 (6): 2924–2941. 2020. doi:10.1093/nar/gkaa051. PMID 31996893.
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