Biology:WDR5

Short description: Protein-coding gene in the species Homo sapiens

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.^[1]^[2]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.^[2]

Interactions

WDR5 has been shown to interact with Host cell factor C1^[3]^[4] and MLL.^[3] It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.^[5]^[6] WDR5 is a key determinant for MYC recruitment to chromatin^[7]

References

↑ "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". The Journal of Biological Chemistry 276 (49): 46515–46522. December 2001. doi:10.1074/jbc.M105757200. PMID 11551928.
↑ ^2.0 ^2.1 "Entrez Gene: WDR5 WD repeat domain 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11091.
↑ ^3.0 ^3.1 "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology 24 (13): 5639–5649. July 2004. doi:10.1128/MCB.24.13.5639-5649.2004. PMID 15199122.
↑ "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development 17 (7): 896–911. April 2003. doi:10.1101/gad.252103. PMID 12670868.
↑ "Non-coding RNAs in CD8 T cell biology". Molecular Immunology 120: 67–73. April 2020. doi:10.1016/j.molimm.2020.01.023. PMID 32085976.
↑ "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature 472 (7341): 120–124. April 2011. doi:10.1038/nature09819. PMID 21423168. Bibcode: 2011Natur.472..120W.
↑ "Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC". Molecular Cell 58 (3): 440–452. May 2015. doi:10.1016/j.molcel.2015.02.028. PMID 25818646.

"BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro.". Endocrinology 145 (3): 1050–1054. 2004. doi:10.1210/en.2003-1314. PMID 14657013.
"Nucleolar proteome dynamics". Nature 433 (7021): 77–83. January 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
"WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development". Cell 121 (6): 859–872. June 2005. doi:10.1016/j.cell.2005.03.036. PMID 15960974.
"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF". Cell 121 (6): 873–885. June 2005. doi:10.1016/j.cell.2005.04.031. PMID 15960975.
"Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
"Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo.". Journal of Musculoskeletal & Neuronal Interactions 5 (4): 338–339. 2006. PMID 16340128.
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–814. May 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
"Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nature Structural & Molecular Biology 13 (8): 704–712. August 2006. doi:10.1038/nsmb1119. PMID 16829959.
"Molecular recognition of histone H3 by the WD40 protein WDR5.". Nature Structural & Molecular Biology 13 (8): 698–703. 2006. doi:10.1038/nsmb1116. PMID 16829960.
"Regulation of MLL1 H3K4 methyltransferase activity by its core components". Nature Structural & Molecular Biology 13 (8): 713–719. August 2006. doi:10.1038/nsmb1128. PMID 16878130.
"Structural basis for molecular recognition and presentation of histone H3 by WDR5". The EMBO Journal 25 (18): 4245–4252. September 2006. doi:10.1038/sj.emboj.7601316. PMID 16946699.
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
"WDR5 is a conserved regulator of protein synthesis gene expression". Nucleic Acids Research 48 (6): 2924–2941. April 2020. doi:10.1093/nar/gkaa051. PMID 31996893.