Biology:WHSC1L1

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene.[1][2]

This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.[2]

The WHSC1L1 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.[3][4]

References

  1. "The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?". FEBS Lett 473 (1): 1–5. Jun 2000. doi:10.1016/S0014-5793(00)01449-6. PMID 10802047. 
  2. 2.0 2.1 "Entrez Gene: WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54904. 
  3. Kang, D; Cho, HS; Toyokawa, G; Kogure, M; Yamane, Y; Iwai, Y; Hayami, S; Tsunoda, T et al. (Feb 2013). "The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.". Genes, Chromosomes & Cancer 52 (2): 126–39. doi:10.1002/gcc.22012. PMID 23011637. 
  4. Chen, Y; McGee, J; Chen, X; Doman, TN; Gong, X; Zhang, Y; Hamm, N; Ma, X et al. (2014). "Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets.". PLOS ONE 9 (5): e98293. doi:10.1371/journal.pone.0098293. PMID 24874471. Bibcode2014PLoSO...998293C. 

Further reading