Biology:WNK3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.[1]
Function
WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.[1]
References
Further reading
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. 2000. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex". J. Clin. Invest. 117 (11): 3403–11. 2007. doi:10.1172/JCI32033. PMID 17975670.
- "WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl− cotransporters required for normal blood pressure homeostasis". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16777–82. 2005. doi:10.1073/pnas.0508303102. PMID 16275913. Bibcode: 2005PNAS..10216777R.
- "Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter". Curr. Opin. Nephrol. Hypertens. 18 (5): 421–7. 2009. doi:10.1097/MNH.0b013e32832f2fcb. PMID 19636250.
- "WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl− cotransporter". Am. J. Physiol. Renal Physiol. 295 (4): F1199-206. 2008. doi:10.1152/ajprenal.90396.2008. PMID 18701621.
- "Renal and brain isoforms of WNK3 have opposite effects on NCCT expression". J. Am. Soc. Nephrol. 20 (6): 1314–22. 2009. doi:10.1681/ASN.2008050542. PMID 19470686.
- "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III 318 (2): 263–72. 1995. PMID 7757816.
- "Molecular physiology of the WNK kinases". Annu. Rev. Physiol. 70: 329–55. 2008. doi:10.1146/annurev.physiol.70.113006.100651. PMID 17961084.
- "WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway". Am. J. Physiol. Renal Physiol. 295 (5): F1472-84. 2008. doi:10.1152/ajprenal.90229.2008. PMID 18768590.
- "Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway". Oncogene 25 (30): 4172–82. 2006. doi:10.1038/sj.onc.1209449. PMID 16501604.
- "Emerging roles for WNK kinases in cancer". Cell. Mol. Life Sci. 67 (8): 1265–76. 2010. doi:10.1007/s00018-010-0261-6. PMID 20094755.
- "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121.
- "Autism-associated familial microdeletion of Xp11.22". Clin. Genet. 74 (2): 134–44. 2008. doi:10.1111/j.1399-0004.2008.01028.x. PMID 18498374.
- "Human hypertension caused by mutations in WNK kinases". Science 293 (5532): 1107–12. 2001. doi:10.1126/science.1062844. PMID 11498583.
- "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members". J. Biol. Chem. 285 (33): 25161–7. 2010. doi:10.1074/jbc.M110.103432. PMID 20525693.
- "Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)". Gene 335: 109–19. 2004. doi:10.1016/j.gene.2004.03.009. PMID 15194194.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene 20 (39): 5562–9. 2001. doi:10.1038/sj.onc.1204726. PMID 11571656.
- "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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