Biology:Wee1-like protein kinase
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[1]
Function
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[2]
Interactions
Wee1-like protein kinase has been shown to interact with YWHAB[3] and PIN1.[4]
References
- ↑ "Wee1(+)-like gene in human cells". Nature 353 (6339): 80–3. September 1991. doi:10.1038/353080a0. PMID 1840647. Bibcode: 1991Natur.353...80I.
- ↑ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7465.
- ↑ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. (UNITED STATES) 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.
- ↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. (UNITED STATES) 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMID 9499405.
Further reading
- "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. 2004. doi:10.1089/104454904773819789. PMID 15142377. https://zenodo.org/record/1235217.
- "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. 2004. doi:10.1196/annals.1321.013. PMID 15265780. Bibcode: 2004NYASA1024..153K. https://zenodo.org/record/1235880.
- "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. 2006. doi:10.1186/1742-4690-2-11. PMID 15725353.
- "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. 2005. doi:10.1038/sj.cr.7290279. PMID 15780175.
- "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. 2005. PMID 15817944.
- "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11–12): 923–34. 2006. doi:10.1038/sj.cr.7290370. PMID 16354571.
- "Wee1(+)-like gene in human cells.". Nature 353 (6339): 80–3. 1991. doi:10.1038/353080a0. PMID 1840647. Bibcode: 1991Natur.353...80I.
- "Subcellular localisation of human wee1 kinase is regulated during the cell cycle.". J. Cell Sci. 108 (6): 2425–32. 1995. doi:10.1242/jcs.108.6.2425. PMID 7673359.
- "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.". EMBO J. 14 (9): 1878–91. 1995. doi:10.1002/j.1460-2075.1995.tb07180.x. PMID 7743995.
- "Cell cycle regulation of human WEE1.". EMBO J. 14 (10): 2166–75. 1995. doi:10.1002/j.1460-2075.1995.tb07210.x. PMID 7774574.
- "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.". Oncogene 9 (10): 3005–11. 1994. PMID 8084605.
- "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.". Cell 74 (3): 463–74. 1993. doi:10.1016/0092-8674(93)80048-J. PMID 8348613.
- "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.". EMBO J. 12 (1): 75–85. 1993. doi:10.1002/j.1460-2075.1993.tb05633.x. PMID 8428596.
- "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization.". Genomics 15 (1): 194–6. 1993. doi:10.1006/geno.1993.1032. PMID 8432534.
- "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.". J. Biol. Chem. 272 (35): 22300–6. 1997. doi:10.1074/jbc.272.35.22300. PMID 9268380.
- "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. 1998. doi:10.1073/pnas.95.12.6785. PMID 9618490. Bibcode: 1998PNAS...95.6785Z.
- "Mechanisms of G2 arrest in response to overexpression of p53.". Mol. Biol. Cell 10 (11): 3607–22. 1999. doi:10.1091/mbc.10.11.3607. PMID 10564259.
- "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population.". Cell Growth Differ. 11 (4): 211–9. 2000. PMID 10775038.
- "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1).". Cytogenet. Cell Genet. 93 (3–4): 277–83. 2001. doi:10.1159/000056998. PMID 11528126.
- "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70. 2001. doi:10.1006/viro.2001.1007. PMID 11531413.
External links
- WEE1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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