Biology:Xylomannan
Xylomannan is an antifreeze molecule, found in the freeze-tolerant Alaskan beetle Upis ceramboides.[1] Unlike antifreeze proteins, xylomannan is not a protein. Instead, it is a combination of a sugar (saccharide) and a fatty acid that is found in cell membranes.[2] As such is expected to work in a different manner than AFPs. It is believed to work by incorporating itself directly into the cell membrane and preventing the freezing of water molecules within the cell.[3] Xylomannan is also found in the red seaweed Nothogenia fastigiata (Scinaiaceae family). Fraction F6 of a sulphated xylomannan from Nothogenia fastigiata was found to inhibit replication of a variety of viruses, including Herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Human cytomegalovirus (HCMV, HHV-5), Respiratory syncytial virus (RSV), Influenzavirus A, Influenzavirus B, Junin and Tacaribe virus, Simian immunodeficiency virus, and (weakly) Human immunodeficiency virus types 1 and 2.[4]
References
- ↑ Walters KR Jr; Serianni AS; Sformo T; Barnes BM; Duman JG (2009). "A nonprotein thermal hysteresis-producing xylomannan antifreeze in the freeze-tolerant Alaskan beetle Upis ceramboides". PNAS 106 (48): 20210–5. doi:10.1073/pnas.0909872106. PMID 19934038. Bibcode: 2009PNAS..10620210W.
- ↑ "Synthetic study and structural analysis of the antifreeze agent xylomannan from Upis ceramboides". J Am Chem Soc 133 (48): 19524–35. Dec 7, 2011. doi:10.1021/ja208528c. PMID 22029271.
- ↑ "New Antifreeze Molecule Isolated In Alaska Beetle - Science News - redOrbit". http://www.redorbit.com/news/science/1799347/new_antifreeze_molecule_isolated_in_alaska_beetle/index.html?source=r_science/.
- ↑ "Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata". Biochemical Pharmacology 47 (12): 2187–92. June 1994. doi:10.1016/0006-2952(94)90254-2. PMID 8031312.
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