Biology:YEATS domain

From HandWiki
Short description: Protein domain found in a variety of proteins from eukaryotic organisms
YEATS domain
Identifiers
SymbolYEATS
PfamPF03366
InterProIPR005033
PROSITEPS51037

In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms.[1] YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold.[2] The YEATS domain has shown to bind to acetyllysine protein modifications.[3] In addition to lysine acetylation, the YEATS domain has shown to be a reader domain for various lysine acylations, with highest affinity for lysine crotonylation.[4] [5]

See also

Bromodomain

References

  1. "YEATS domain proteins: a diverse family with many links to chromatin modification and transcription". Biochem. Cell Biol. 87 (1): 65–75. 2009. doi:10.1139/O08-111. PMID 19234524. 
  2. "Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation". Proc. Natl. Acad. Sci. U.S.A. 106 (51): 21573–8. 2009. doi:10.1073/pnas.0906539106. PMID 19966225. 
  3. "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell 159 (3): 558–71. 2014. doi:10.1016/j.cell.2014.09.049. PMID 25417107. 
  4. "Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain". Molecular Cell 62 (2): 181–193. 2016. doi:10.1016/j.molcel.2016.03.028. PMID 27105114. 
  5. "The Taf14 YEATS domain is a reader of histone crotonylation". Nat. Chem. Biol. 12 (6): 396–8. 2016. doi:10.1038/nchembio.2065. PMID 27089029.