Biology:ZBTB14
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger and BTB domain-containing protein 14 is a protein that in humans is encoded by the ZBTB14 gene (previously ZFP161).[1][2] The ZBTB14 protein acts as a transcription activator for the dopamine transporter, while instead acting as a transcription repressor for FMR1, MYC, and thymidine kinases.[3]
See also
- Chromosome 18 (human)
- Sequence homology
- Zinc finger
- BTB/POZ domain
References
- ↑ "The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)". Genomics 43 (2): 156–64. Sep 1997. doi:10.1006/geno.1997.4784. PMID 9244432.
- ↑ "Entrez Gene: ZFP161 zinc finger protein 161 homolog (mouse)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7541.
- ↑ "O43829 · ZBT14_HUMAN". UniProt consortium. https://www.uniprot.org/uniprotkb/O43829/entry.
Further reading
- Numoto M; Niwa O; Kaplan J et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMID 8367294.
- Sugiura K; Muro Y; Nagai Y et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-6. PMID 9177479.
- Obata T; Yanagidani A; Yokoro K et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
- "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. 1999. doi:10.1006/bbrc.1999.0375. PMID 10080939.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Lee KH; Kwak YD; Kim DH et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. 2005. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
- Orlov SV; Kuteĭkin-Tepliakov KB; Grishin AV et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia 48 (3): 246–52. PMID 16805315.
- Orlov SV; Kuteykin-Teplyakov KB; Ignatovich IA et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511.
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