Biology:ZEB2-AS1
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 Generic protein structure example |
ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene.[1][2] It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.[2]
See also
- Long noncoding RNA
References
- ↑ "Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1". Genomics 82 (4): 460–469. October 2003. doi:10.1016/S0888-7543(03)00169-1. PMID 13679026.
- ↑ 2.0 2.1 "A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition". Genes Dev. 22 (6): 756–769. March 2008. doi:10.1101/gad.455708. PMID 18347095.
Further reading
- "Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition". Trends Cell Biol. 18 (8): 357–359. August 2008. doi:10.1016/j.tcb.2008.05.005. PMID 18585040.
- "Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy". J. Biol. Chem. 285 (41): 31148–31156. October 2010. doi:10.1074/jbc.M110.132332. PMID 20682777.
- Mattick JS (April 2009). "The genetic signatures of noncoding RNAs". PLOS Genet. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMID 19390609.
External links
- Page for ZEB2-AS1-1 at Rfam
- Page for ZEB2-AS1-2 at Rfam
- Page for ZEB2-AS1-3 at Rfam
- Page for ZEB2-AS1-4 at Rfam
Gallery of ZEB2-AS1 conserved RNA secondary structure images | |
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