Biology:ZNF444

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene.

Function

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) ("Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem 277 (27): 24014–21. 2002. doi:10.1074/jbc.M201854200. PMID 11978792. ). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J. Biol. Chem. 277 (27): 24014–21. 2002. doi:10.1074/jbc.M201854200. PMID 11978792. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.