Chemistry:ADX-47273
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Short description: Chemical compound
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| Formula | C20H17F2N3O2 |
| Molar mass | 369.372 g·mol−1 |
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ADX-47273 is a research pharmaceutical developed by Addex Therapeutics which acts as a positive allosteric modulator (PAM) selective for the metabotropic glutamate receptor subtype mGluR5.[1][2] It has nootropic and antipsychotic effects in animal studies,[3] and has been used as a lead compound to develop improved derivatives.[4]
See also
References
- ↑ "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry 49 (11): 3332–44. June 2006. doi:10.1021/jm051252j. PMID 16722652.
- ↑ Stauffer, Shaun R. (17 August 2011). "Progress toward Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 (mGlu5)". ACS Chemical Neuroscience 2 (8): 450–470. doi:10.1021/cn2000519. PMID 22860171.
- ↑ "ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities". The Journal of Pharmacology and Experimental Therapeutics 327 (3): 827–39. December 2008. doi:10.1124/jpet.108.136580. PMID 18753411.
- ↑ "Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273". ChemMedChem 4 (4): 505–11. April 2009. doi:10.1002/cmdc.200800357. PMID 19197923.
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