Chemistry:AZ12216052
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C19H22BrNOS |
| Molar mass | 392.36 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
AZ-12216052 is a drug which acts as a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 8, and is used for research into the role of this receptor subtype in various processes including anxiety and neuropathic pain.[1][2][3][4][5]
References
- ↑ "Acute pharmacological modulation of mGluR8 reduces measures of anxiety". Behavioural Brain Research 212 (2): 168–173. October 2010. doi:10.1016/j.bbr.2010.04.006. PMID 20385173.
- ↑ "Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds". Neuropharmacology 67: 88–94. April 2013. doi:10.1016/j.neuropharm.2012.09.023. PMID 23164615.
- ↑ "Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions". Journal of Neurophysiology 111 (11): 2196–2209. June 2014. doi:10.1152/jn.00212.2013. PMID 24304862.
- ↑ "Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation". Neurochemistry International 88: 124–137. September 2015. doi:10.1016/j.neuint.2014.12.011. PMID 25661514.
- ↑ "Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State". Basic & Clinical Pharmacology & Toxicology 123 (4): 443–451. October 2018. doi:10.1111/bcpt.13041. PMID 29753314.
 |  |
