Chemistry:Agrimol B
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| Formula | C37H46O12 |
| Molar mass | 682.763 g·mol−1 |
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Agrimol B is a natural product which is found in the plant Agrimonia pilosa, which is used in traditional herbal medicine in various countries in East Asia. It has a complex spectrum of activity, acting as an activator of the SIRT1 protein but an inhibitor of various other enzyme targets. In animal studies it has anti-obesity, anti-parasitic and anti-cancer effects.[1][2][3][4][5][6]
References
- ↑ "Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway". Biochemical and Biophysical Research Communications 477 (3): 454–460. August 2016. doi:10.1016/j.bbrc.2016.06.078. PMID 27320865.
- ↑ "Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest". Biomedicine & Pharmacotherapy 141. September 2021. doi:10.1016/j.biopha.2021.111795. PMID 34098217.
- ↑ "Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway". Frontiers in Oncology 12. 2022. doi:10.3389/fonc.2022.1055126. PMID 36591497.
- ↑ "Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice". Acta Biochimica et Biophysica Sinica 56 (4): 551–563. April 2024. doi:10.3724/abbs.2023285. PMID 38404180.
- ↑ "Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma". Free Radical Biology & Medicine 220: 111–124. August 2024. doi:10.1016/j.freeradbiomed.2024.04.242. PMID 38697493.
- ↑ "Activating the iNOS regulatory pathway by arginine deprivation targets energy metabolism to induce autophagy-dependent apoptosis against spinal echinococcosis". Biochemical Pharmacology 227. September 2024. doi:10.1016/j.bcp.2024.116453. PMID 39059773.
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