Chemistry:Allisartan isoproxil
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| Formula | C27H29ClN6O5 |
| Molar mass | 553.02 g·mol−1 |
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Allisartan isoproxil is an antihypertensive pharmaceutical drug.[1][2][3] It belongs to the angiotensin II receptor blocker class of drugs. It is an esterified prodrug,[2] and its metabolism results in the formation of a single metabolite, losartan carboxylic acid (EXP3174), an oxidized form of losartan.
Chemical structure of losartan carboxylic acid
In China, allisartan isoproxil was approved by the Chinese Food and Drug Administration for the treatment of hypertension in 2012, and introduced to the market in 2013.[4]
References
- ↑ "Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension". Medicine 98 (12). March 2019. doi:10.1097/MD.0000000000014907. PMID 30896643.
- ↑ 2.0 2.1 "Efficacy and safety evaluation of Allisartan Isoproxil in patients with hypertension: a meta-analysis". Frontiers in Cardiovascular Medicine 11. 2024. doi:10.3389/fcvm.2024.1355014. PMID 38903964.
- ↑ "Efficacy of Allisartan Isoproxil in the Treatment of Mild-to-Moderate Essential Hypertension". American Journal of Hypertension 36 (10): 561–567. September 2023. doi:10.1093/ajh/hpad055. PMID 37343187.
- ↑ "Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage". Acta Pharmacologica Sinica 42 (6): 871–884. June 2021. doi:10.1038/s41401-021-00684-7. PMID 34002042.
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