Chemistry:BAM15
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Preferred IUPAC name
N5,N6-Bis(2-fluorophenyl)[2,1,3]oxadiazolo[4,5-b]pyrazine-5,6-diamine | |
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Properties | |
C16H10F2N6O | |
Molar mass | 340.294 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced kidney tubule damage.[1][2] It is being studied for the treatment of obesity[3] sepsis,[1][4] and cancer.[5][6]
References
- ↑ Jump up to: 1.0 1.1 Tsuji, Naoko; Tsuji, Takayuki; Yamashita, Tetsushi; Hayase, Naoki; Hu, Xuzhen; Yuen, Peter S. T.; Star, Robert A. (3 April 2023). "BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils" (in en). The Journal of Clinical Investigation 133 (7). doi:10.1172/JCI152401. ISSN 0021-9738. PMID 36757801. PMC 10065071. https://www.jci.org/articles/view/152401.
- ↑ Alexopoulos, Stephanie J.; Chen, Sing-Young; Brandon, Amanda E.; Salamoun, Joseph M.; Byrne, Frances L.; Garcia, Christopher J.; Beretta, Martina; Olzomer, Ellen M. et al. (2020). "Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice". Nature Communications 11 (1): 2397. doi:10.1038/s41467-020-16298-2. PMID 32409697. Bibcode: 2020NatCo..11.2397A.
- ↑ Axelrod, Christopher L; King, William T; Davuluri, Gangarao; Noland, Robert C; Hall, Jacob; Hull, Michaela; Dantas, Wagner S; Zunica, Elizabeth RM et al. (7 July 2020). "BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control". EMBO Molecular Medicine 12 (7): e12088. doi:10.15252/emmm.202012088. ISSN 1757-4676. PMID 32519812.
- ↑ Dang, Cong Phi; Issara-Amphorn, Jiraphorn; Charoensappakit, Awirut; Udompornpitak, Kanyarat; Bhunyakarnjanarat, Thansita; Saisorn, Wilasinee; Sae-Khow, Kritsanawan; Leelahavanichkul, Asada (1 June 2021). "BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes". Journal of Innate Immunity 13 (6): 359–375. doi:10.1159/000516348. ISSN 1662-811X. PMID 34062536. PMC 8613553. https://karger.com/jin/article/13/6/359/824259/BAM15-a-Mitochondrial-Uncoupling-Agent-Attenuates.
- ↑ Gao, Zhen xing; Cui, Ze long; Zhou, Min ran; Fu, Yue; Liu, Fen; Zhang, Lu; Ma, Sai; Chen, Chun yan (1 April 2022). "The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia". Biochemical Pharmacology 198: 114948. doi:10.1016/j.bcp.2022.114948. ISSN 0006-2952. PMID 35192847. https://www.sciencedirect.com/science/article/abs/pii/S0006295222000429.
- ↑ Zunica, Elizabeth R. M.; Axelrod, Christopher L.; Cho, Eunhan; Spielmann, Guillaume; Davuluri, Gangarao; Alexopoulos, Stephanie J.; Beretta, Martina; Hoehn, Kyle L. et al. (9 October 2021). "Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-bpyrazine BAM15"]. Cancer & Metabolism 9 (1): 36. doi:10.1186/s40170-021-00274-5. ISSN 2049-3002. PMID 34627389.
External links
Original source: https://en.wikipedia.org/wiki/BAM15.
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