Chemistry:BD1018

Short description: Chemical compound

BD1018

Identifiers
IUPAC name (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine
CAS Number	150208-42-7
PubChem CID	9796317
ChemSpider	7972083
Chemical and physical data
Formula	C15H20Cl2N2
Molar mass	299.24 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1Cl)CCN3C[C@H]2N(CCC2)CC3
InChI InChI=1S/C15H20Cl2N2/c16-14-4-3-12(10-15(14)17)5-7-18-8-9-19-6-1-2-13(19)11-18/h3-4,10,13H,1-2,5-9,11H2/t13-/m0/s1 Key:IGVDQXLOMXGWKN-ZDUSSCGKSA-N

BD1018 or (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor ligand, with a reported binding affinity of K_i = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor. Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist.

Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice.

See also

• BD1008
• BD1031