Chemistry:BMS-986224

From HandWiki

BMS-986224 is a drug which is a selective, small-molecule agonist for the apelin receptor. It has been researched for the treatment of heart failure.[1][2][3]

See also

References

  1. ↑ "Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists". Bioorganic & Medicinal Chemistry Letters 50. October 2021. doi:10.1016/j.bmcl.2021.128325. PMID 34403724. 
  2. ↑ "Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate". Journal of Medicinal Chemistry 64 (6): 3086–3099. March 2021. doi:10.1021/acs.jmedchem.0c01878. PMID 33689340. 
  3. ↑ "In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure". Circulation. Heart Failure 14 (3). March 2021. doi:10.1161/CIRCHEARTFAILURE.120.007351. PMID 33663236. 



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