Chemistry:CMF-019
From HandWiki
CMF-019 is a drug which is a selective, small-molecule agonist for the apelin receptor. It is used in research into treatment for heart failure.[1][2][3]
See also
References
- ↑ "Cardiac action of the first G protein biased small molecule apelin agonist". Biochemical Pharmacology 116: 63–72. September 2016. doi:10.1016/j.bcp.2016.07.018. PMID 27475715.
- ↑ "An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist". Medicinal Chemistry 14 (7): 688–694. 2018. doi:10.2174/1573406414666180412154952. PMID 29651942.
- ↑ "Identification of potent pyrazole based APELIN receptor (APJ) agonists". Bioorganic & Medicinal Chemistry 28 (4). February 2020. doi:10.1016/j.bmc.2019.115237. PMID 31948845.
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