Chemistry:BMS641

From HandWiki

BMS641 (BMS-209641) is a drug which acts as a retinoic acid receptor β (RARβ) agonist. It is used for research into the function of RARβ in roles such as tissue differentiation during embryonic development, and the development of some forms of cancer.[1][2][3][4]

References

  1. ↑ "Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells". Biochemical Pharmacology 69 (11): 1595–1601. 1 June 2005. doi:10.1016/j.bcp.2005.02.024. PMID 15896339. 
  2. ↑ "An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist". PLOS ONE 10 (5). 1 May 2015. doi:10.1371/journal.pone.0123195. PMID 25933005. 
  3. ↑ "Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs". Life Science Alliance 6 (2). 29 November 2022. doi:10.26508/lsa.202201627. PMID 36446525. 
  4. ↑ "Decoding transcriptional identity during neuron-astroglia cell fate driven by RAR-specific agonists". NAR Molecular Medicine 2 (2). April 2025. doi:10.1093/narmme/ugaf018. PMID 41255712. 



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