Chemistry:Balinatunfib
From HandWiki
Balinatunfib (SAR441566) is an experimental drug which acts as a potent small molecule inhibitor of TNF-α. Rather than blocking TNF-α receptors, balinatunfib inactivates TNF-α directly by stabilising an inactive form of the TNF-α trimer which fails to bind to its target receptors. It is in early stage clinical trials for rheumatoid arthritis and other chronic autoimmune diseases.[1][2]
See also
References
- ↑ "An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis". Frontiers in Pharmacology 13. 2022. doi:10.3389/fphar.2022.1037983. PMID 36467083.
- ↑ "Exploring TNFR1: from discovery to targeted therapy development". Journal of Translational Medicine 23 (1): 71. January 2025. doi:10.1186/s12967-025-06122-0. PMID 39815286.
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