Chemistry:R-7050

From HandWiki

R-7050 is an experimental drug which acts as an antagonist for the receptors for TNF-α. It has antiinflammatory effects and is used in pharmacological research into various inflammatory processes mediated via TNF-α signalling.[1][2][3][4][5][6]

See also

References

  1. ↑ "TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice". Neuroscience Letters 542: 92–96. May 2013. doi:10.1016/j.neulet.2013.02.051. PMID 23499961. 
  2. ↑ "Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats". Molecular Medicine Reports 12 (2): 3095–3100. August 2015. doi:10.3892/mmr.2015.3744. PMID 25955232. 
  3. ↑ "Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats". Journal of Translational Medicine 17 (1). August 2019. doi:10.1186/s12967-019-2006-0. PMID 31391086. 
  4. ↑ "TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke". Antioxidants 10 (6): 851. May 2021. doi:10.3390/antiox10060851. PMID 34073455. 
  5. ↑ "Single-cell RNA-sequencing analysis reveals α-syn induced astrocyte-neuron crosstalk-mediated neurotoxicity". International Immunopharmacology 139. September 2024. doi:10.1016/j.intimp.2024.112676. PMID 39053230. 
  6. ↑ "TNF-α Enhanced Activity of Sympathetic Neurons in Superior Cervical Ganglion to Promote Chronic Sleep Deprivation-Related Hyperalgesia". Molecular Neurobiology 62 (7): 8298–8312. February 2025. doi:10.1007/s12035-025-04790-z. PMID 39992586. 



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