Chemistry:Barakol
From HandWiki
Short description: Chemical compound
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| Formula | C13H12O4 |
| Molar mass | 232.235 g·mol−1 |
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Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects.[2][3] There are contradictory pharmacological research findings concerning the toxicity of Cassia siamea and the active ingredient Barakol. One pharmacological study has shown an hepatoxic effect of Barakol [4] while another study did not show any toxic effect at a daily dosage intake.[5] Further research is needed to verify whether there are toxic effects of Barakol or not.
References
- ↑ "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health 37 (2): 388–93. March 2006. PMID 17125004.
- ↑ "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology 319 (2–3): 157–64. January 1997. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586.
- ↑ "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology 83 (1–2): 87–94. November 2002. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711.
- ↑ "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet 86 (Suppl 2): S484-9. June 2003. PMID 12930029.
- ↑ "Toksisitas Subkronik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih [The subchronic toxicity study of the ethanolic extract of Cassia siamea lamk leaf (daun johar) on albino rats"]. Bulletin of Health Research = Buletin Penelitian Kesehatan = National Institute of Health Research and Development - Ministry of Health of Republic of Indonesia 27 Suppl. 3 & 4: S325–332. December 1999. http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/275/359.
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