Chemistry:Benzamidenafil
From HandWiki
Benzamidenafil (Xanthoanthrafil) is a synthetic drug that acts as a PDE5 inhibitor. It has the same mechanism of action as pharmaceutical drugs used to treat erectile dysfunction,[1] but it is not approved by any regulatory agency for such use. The (R) enantiomer is the active form, and was previously patented under the code FR226807.[2][3] It has also been used for research into other potential therapeutic applications of PDE5 inhibitors such as in the treatment of nephrotoxicity.[4]
The drug has been found as an undeclared adulterant in supposedly "natural" health supplements.[1] In 2009, the supplement manufacturer Hi-Tech Pharmaceuticals recalled its product Stamina-Rx because it was adulterated with benzamidenafil.[5]
See also
References
- ↑ 1.0 1.1 Zou, Peng; Hou, Peiling; Oh, Sharon Sze-Yin; Ge, Xiaowei; Bloodworth, Bosco Chen; Low, Min-Yong; Koh, Hwee-Ling (2008). "Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement". Journal of Pharmaceutical and Biomedical Analysis 47 (2): 255–259. doi:10.1016/j.jpba.2008.01.004. PMID 18280079.
- ↑ Hosogai N, Hamada K, Tomita M, Nagashima A, Takahashi T, Sekizawa T, Mizutani T, Urano Y, Kuroda A, Sawada K, Ozaki T, Seki J, Goto T. FR226807: a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2001 Oct 5;428(2):295-302. doi:10.1016/s0014-2999(01)01345-0 PMID 11675048
- ↑ Kumasaka K, Kawahara N, Doi K, Kojima T, Goda Y. Determination of (R)-xanthoanthrafil, a phosphodiesterase-5 inhibitor, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Feb;56(2):227-30. doi:10.1248/cpb.56.227 PMID 18239316
- ↑ Hosogai N, Tomita M, Hamada K, Ogawa T, Hirosumi J, Manda T, Mutoh S. Phosphodiesterase type 5 inhibition ameliorates nephrotoxicity induced by cyclosporin A in spontaneous hypertensive rats. Eur J Pharmacol. 2003 Sep 12;477(2):171-8. doi:10.1016/j.ejphar.2003.08.014 PMID 14519421
- ↑ Miranda Hitti. "Stamina-Rx Supplements Recalled" (in en). https://www.webmd.com/erectile-dysfunction/news/20090617/stamina-rx-supplements-recalled.
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