Chemistry:Biphenylindanone A
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Short description: Chemical compound
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| Formula | C30H30O4 |
| Molar mass | 454.566 g·mol−1 |
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Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.
In animal studies it showed anxiolytic and antipsychotic effects,[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.[2]
BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR2/3 agonist LY-379,268.[3]
References
- ↑ "Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice". The Journal of Pharmacology and Experimental Therapeutics 318 (1): 173–85. July 2006. doi:10.1124/jpet.106.102046. PMID 16608916.
- ↑ "A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis". Molecular Pharmacology 72 (2): 477–84. August 2007. doi:10.1124/mol.107.035170. PMID 17526600.
- ↑ "The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats". Neuropsychopharmacology 35 (10): 2021–36. September 2010. doi:10.1038/npp.2010.82. PMID 20555310.
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