Chemistry:C16 (drug)
From HandWiki
Short description: Chemical compound
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| Formula | C13H8N4OS |
| Molar mass | 268.29 g·mol−1 |
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C16 (PKRi, GW 506033X) is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.[1][2][3][4][5][6][7][8]
See also
References
- ↑ "Small molecule inhibitors of the RNA-dependent protein kinase". Biochemical and Biophysical Research Communications 308 (1): 50–57. August 2003. doi:10.1016/s0006-291x(03)01318-4. PMID 12890478.
- ↑ "Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress". Neuroscience Letters 409 (3): 192–195. December 2006. doi:10.1016/j.neulet.2006.09.074. PMID 17055645.
- ↑ "The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation". FEBS Letters 581 (23): 4473–4478. September 2007. doi:10.1016/j.febslet.2007.08.022. PMID 17761171.
- ↑ "A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase"]. The European Journal of Neuroscience 28 (10): 2003–2016. November 2008. doi:10.1111/j.1460-9568.2008.06491.x. PMID 19046382.
- ↑ "Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice". The Journal of Biological Chemistry 285 (2): 1272–1282. January 2010. doi:10.1074/jbc.M109.041954. PMID 19889624.
- ↑ "Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition". Cell 147 (6): 1384–1396. December 2011. doi:10.1016/j.cell.2011.11.029. PMID 22153080.
- ↑ "Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition". Molecular Brain 10 (1): 57. December 2017. doi:10.1186/s13041-017-0338-3. PMID 29233183.
- ↑ "PKR: A Kinase to Remember". Frontiers in Molecular Neuroscience 11: 480. 2018. doi:10.3389/fnmol.2018.00480. PMID 30686999.
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