Chemistry:S-17092
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Short description: Chemical compound
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| Formula | C23H29FN2O2 |
| Molar mass | 384.495 g·mol−1 |
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S-17092 is a drug which acts as a selective inhibitor of the enzyme prolyl endopeptidase.[1] This enzyme is involved in the metabolic breakdown of a number of neuropeptide neurotransmitters in the brain,[2][3] and so inhibiting the action of the enzyme increases the activity of these neuropeptides. This produces nootropic effects which make S-17092 a promising and novel treatment for neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease.[4][5]
See also
- C16 (PKR inhibitor)
- UK-414,495
References
- ↑ "S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase". Biochemical and Biophysical Research Communications 257 (3): 657–61. April 1999. doi:10.1006/bbrc.1999.0366. PMID 10208839.
- ↑ "Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain". Journal of Neurochemistry 84 (5): 919–29. March 2003. doi:10.1046/j.1471-4159.2003.01536.x. PMID 12603817.
- ↑ "Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain". Journal of Neuroendocrinology 17 (5): 306–13. May 2005. doi:10.1111/j.1365-2826.2005.01308.x. PMID 15869566.
- ↑ "S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies". CNS Drug Reviews 8 (1): 31–52. 2002. doi:10.1111/j.1527-3458.2002.tb00214.x. PMID 12070525.
- ↑ "Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers". Neuropsychobiology 55 (3–4): 176–83. 2007. doi:10.1159/000107070. PMID 17700042.
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