Chemistry:CECXG
From HandWiki
Short description: Chemical compound
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| Formula | C22H23NO5 |
| Molar mass | 381.428 g·mol−1 |
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CECXG (3'-ethyl-LY-341,495) is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with reasonable selectivity for mGluR3. While it is some five times less potent than LY-341,495 at mGluR3, it has 38x higher affinity for mGluR3 over mGluR2,[1] making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes.[2][3][4]
References
- ↑ "2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors". Bioorganic & Medicinal Chemistry Letters 8 (20): 2849–2854. October 1998. doi:10.1016/S0960-894X(98)00510-1. PMID 9873635.
- ↑ "Pharmacology of metabotropic glutamate receptors". Glutamate and GABA receptors and transporters: structure, function and pharmacology. Taylor & Francis. 2002. pp. 171–173. ISBN 0-7484-0881-9.
- ↑ "Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands". Bioorganic & Medicinal Chemistry 11 (2): 197–205. January 2003. doi:10.1016/S0968-0896(02)00387-5. PMID 12470714.
- ↑ "Metabotropic glutamate receptors and epilepsy". Journal of the Neurological Sciences 247 (1): 1–9. August 2006. doi:10.1016/j.jns.2006.03.018. PMID 16697014.
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