Chemistry:CSPD (molecule)
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| IUPAC name
3-(1-Chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane]-3'-yl)phenyl] dihydrogen phosphate
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| Identifiers | |
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3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C18H22ClO7P | |
| Molar mass | 416.79 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
CSPD ([3-(1-chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane]-3'-yl)phenyl] dihydrogen phosphate) is a chemical substance with formula C18H22ClO7P. It is a component of enhanced chemiluminescence enzyme-linked immunosorbent assay (ELISA) kits, used for the detection of minute amounts of various substances such as proteins.[1]
Properties
The molecule CSPD has the following functional groups in the structure: phosphate group, phenyl group, spiro group, methyl ether group, and chlorine group. The ones worth noting are the ones above. None of these groups carry a charge. If there was a charge this would have had a change in the compound's pH, 3D structure, mass and bond angles.[2]
The toxin CSPD effect persister cell formation using MqsR (MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli[3]) and persister cells are cells that avoid stress and are characterized by reduced metabolism and other factors.[4][clarification needed]
References
- ↑ Kricka, Larry J (1993). "Ultrasensitive immunoassay techniques". Clinical Biochemistry 26 (5): 325–331. doi:10.1016/0009-9120(93)90108-I. PMID 8299202.
- ↑ PubChem. "[3-(1-Chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane-3'-yl)phenyl] dihydrogen phosphate"] (in en). https://pubchem.ncbi.nlm.nih.gov/compound/64633.
- ↑ "mqsR - mRNA interferase toxin MqsR - Escherichia coli (strain K12) - mqsR gene & protein" (in en). https://www.uniprot.org/uniprot/Q46865#:~:text=%22MqsR,%20a%20crucial%20regulator%20for,mRNA%20interferase%20in%20Escherichia%20coli.%22.
- ↑ Kim, Younghoon; Wood, Thomas K. (2010-01-01). "Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli" (in en). Biochemical and Biophysical Research Communications 391 (1): 209–213. doi:10.1016/j.bbrc.2009.11.033. ISSN 0006-291X. PMID 19909729.
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