Chemistry:Carnosol
From HandWiki
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| IUPAC name
11,12-Dihydroxy-7β,20-epoxyabieta-8,11,13-trien-20-one
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| Systematic IUPAC name
(4aR,9S,10aS)-5,6-Dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydro-2H-9,4a-(epoxymethano)phenanthren-12-one | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C20H26O4 | |
| Molar mass | 330.424 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Carnosol is a phenolic diterpene found in the herbs rosemary (Rosmarinus officinalis)[1] and Mountain desert sage (Salvia pachyphylla).[2]
It has been studied in-vitro for anti-cancer effects in various cancer cell types.[3]
carnosol have defensive consequences against sepsis-induced myocardial and other inflammatory diseases involving the NF-κB signaling pathway, including myocarditis and inflammatory cardiomyopathy. [4]
See also
References
- ↑ Ai-Hsiang Lo; Yu-Chih Liang; Shoei-Yn Lin-Shiau; Chi-Tang Ho; Jen-Kun Lin (2002). "Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages". Carcinogenesis 23 (6): 983–991. doi:10.1093/carcin/23.6.983. PMID 12082020.
- ↑ Ivan C. Guerrero; Lucia S. Andres; Leticia G. Leon; Ruben P. Machin; Jose M. Padron; Javier G. Luis; Jose Delgadillo (2006). "Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines". J. Nat. Prod. 69 (12): 1803–1805. doi:10.1021/np060279i. PMID 17190465.
- ↑ Johnson JJ (June 2011). "Carnosol: a promising anti-cancer and anti-inflammatory agent". Cancer Lett. 305 (1): 1–7. doi:10.1016/j.canlet.2011.02.005. PMID 21382660.
- ↑ Rahimi VB (May 2022). "Carnosol Attenuates LPS-Induced Inflammation of Cardiomyoblasts by Inhibiting NF-κB: A Mechanistic in Vitro and in Silico Study". Evidence-Based Complementary and Alternative Medicine 2022: 1–12. doi:10.1155/2022/7969422. PMID 35571740.
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