Chemistry:Centpropazine
From HandWiki
Centpropazine (CPZ, CTZ) is an experimental antidepressant of the phenylpiperazine family which was under development for the treatment of major depressive disorder in India but was never marketed.[1][2][3] It is described as having imipramine-like clinical effects, reversing reserpine-induced effects in animals, and potentiating amphetamine-induced effects in animals.[3] The mechanism of action of centpropazine is unknown.[4] The drug reached phase 3 clinical trials prior to the discontinuation of its development.[1] It was first described in the scientific literature by 1980.[3][5]
Chemical structures of centpropazine and analogues
-
Centpropazine -
Centpyraquin (IHCH-7162) -
See also
- IHCH-7162 (centpyraquin)
References
- ↑ 1.0 1.1 "Centpropazine". AdisInsight. Springer Nature Switzerland AG. 10 December 2013. https://adisinsight.springer.com/drugs/800001958.
- ↑ "Research on antidepressants in India". Indian Journal of Psychiatry 52 (Suppl 1): S341–S354. January 2010. doi:10.4103/0019-5545.69263. PMID 21836704.
- ↑ 3.0 3.1 3.2 "Chapter 1. Antidepressants". Annual Reports in Medicinal Chemistry. 16. Elsevier. 1981. p. 1–10. doi:10.1016/s0065-7743(08)61268-3. ISBN 978-0-12-040516-9.
- ↑ "Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors". Bulletin of the Korean Chemical Society (Wiley) 44 (7): 596–599. 29 March 2023. doi:10.1002/bkcs.12693. ISSN 1229-5949.
- ↑ "Medicinal chemistry research in India". Progress in Medicinal Chemistry 22: 243–266. 1985. doi:10.1016/s0079-6468(08)70232-7. ISBN 978-0-444-80668-0. PMID 2873624.
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