Chemistry:Centpropazine
From HandWiki
Centpropazine (CPZ, CTZ) is an experimental antidepressant which was under development for the treatment major depressive disorder in India but was never marketed.[1][2][3] It is described as having imipramine-like clinical effects, reversing reserpine-induced effects in animals, and potentiating amphetamine-induced effects in animals.[3] The mechanism of action of centpropazine is unknown.[4] The drug reached phase 3 clinical trials prior to the discontinuation of its development.[1] It was first described in the scientific literature by 1980.[3][5]
See also
- IHCH-7162 (centpyraquin)
References
- ↑ 1.0 1.1 "Centpropazine". AdisInsight. Springer Nature Switzerland AG. 10 December 2013. https://adisinsight.springer.com/drugs/800001958.
- ↑ "Research on antidepressants in India". Indian Journal of Psychiatry 52 (Suppl 1): S341–S354. January 2010. doi:10.4103/0019-5545.69263. PMID 21836704.
- ↑ 3.0 3.1 3.2 "Chapter 1. Antidepressants". Annual Reports in Medicinal Chemistry. 16. Elsevier. 1981. p. 1–10. doi:10.1016/s0065-7743(08)61268-3. ISBN 978-0-12-040516-9.
- ↑ "Identification of 1-phenoxy-3-(piperazin-1-yl)propan-2-ol derivatives as novel triple reuptake inhibitors". Bulletin of the Korean Chemical Society (Wiley) 44 (7): 596–599. 29 March 2023. doi:10.1002/bkcs.12693. ISSN 1229-5949.
- ↑ "Medicinal chemistry research in India". Progress in Medicinal Chemistry 22: 243–266. 1985. doi:10.1016/s0079-6468(08)70232-7. ISBN 978-0-444-80668-0. PMID 2873624.
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