Chemistry:IHCH-7179

From HandWiki

IHCH-7179 is a serotonin and dopamine receptor modulator related to the ergolines and phenylpiperazines.[1][2] It acts as a serotonin 5-HT1A receptor agonist, serotonin 5-HT2A receptor antagonist, and dopamine D2 receptor partial agonist.[1] The drug produces antipsychotic-like effects in rodents, such as prevention of the hyperlocomotion induced by the NMDA receptor antagonist dizocilpine (MK-801).[1] It also blocks the head-twitch response induced by the serotonergic psychedelic LSD.[1] IHCH-7179 was first described in the scientific literature by 2024.[1] It was developed by the Chinese Academy of Sciences and associated organizations in Shanghai, China.[1][2] IHCH-7179 is of interest for potential treatment of schizophrenia.[1][2]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Flexible scaffold-based cheminformatics approach for polypharmacological drug design". Cell 187 (9): 2194–2208.e22. April 2024. doi:10.1016/j.cell.2024.02.034. PMID 38552625. 
  2. ↑ 2.0 2.1 2.2 "Delving into the Latest Updates on IHCH-7179 with Synapse". 8 May 2025. https://synapse.patsnap.com/drug/9681aacdeb29450d904b3bbf86ea2a3d. 





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