Chemistry:Polyvinylpolypyrrolidone
Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).
This cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets.[1]
It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.[2] One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.[3]
Safety
Autopsies have found that crospovidone/PVPP contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[4]
See also
References
- ↑ "Povidones, Copovidones, and Crospovidones for Pharmaceutical Products" (in en-US). https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones.
- ↑ Leiper, Kenneth A.; Stewart, Graham G.; McKeown, Ian P.; Nock, Tony; Thompson, Matthew J. (2005). "Optimising Beer Stabilisation by the Selective Removal of Tannoids and Sensitive Proteins". Journal of the Institute of Brewing (Wiley) 111 (2): 118–127. doi:10.1002/j.2050-0416.2005.tb00657.x. ISSN 0046-9750. "Originally via SLS Heriot-Watt University". alt access
- ↑ "A Novel Stabilization of Beer with Polyclar Brewbrite. Mustafa Rehmanji, Chandra Gopal, and Andrew Mola, MBAA TQ vol. 39, no. 1, 2002, pp. 24–28". http://micro-report.com/wp-content/uploads/ISP_007_Stabilization_of_Beer_with_Polyclar_Brewbrite.pdf.
- ↑ Ganesan, S; Felo, J; Saldana, M; Kalasinsky, V. F.; Lewin-Smith, M. R.; Tomashefski Jr, J. F. (2003). "Embolized crospovidone (polyN-vinyl-2-pyrrolidone) in the lungs of intravenous drug users". Modern Pathology 16 (4): 286–92. doi:10.1097/01.MP.0000062653.65441.DA. PMID 12692192.
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