Chemistry:Polyvinylpyrrolidone

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Short description: Water-soluble polymer
Polyvinylpyrrolidone
150pxc
Sample of polyvinyl pyrrolidone.jpg
Names
IUPAC name
1-Ethenylpyrrolidin-2-one
Other names
PVP, Povidone

PVPP, Crospovidone, Polyvidone
PNVP
Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]
1-Ethenyl-2-pyrrolidon homopolymer
1-Vinyl-2-pyrrolidinon-Polymere,

Kollidon
Poly-N-vinylpyrrolidine
Identifiers
3D model (JSmol)
Abbreviations PVP, PVPP, NVP, PNVP
ChEMBL
ChemSpider
  • none
UNII
Properties
(C6H9NO)n
Molar mass 2,500 – 2,500,000 g·mol−1
Appearance white to light yellow, hygroscopic, amorphous powder
Density 1.2 g/cm3
Melting point 150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Tracking categories (test):

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.[1] PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.[2]

Uses

Medical

Structure of povidone-iodine complex, a common antiseptic[3]

It is used as a binder in many pharmaceutical tablets;[4] it simply passes through the body when taken orally.

PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[5] This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs. It is sold under the trade names Pyodine and Betadine, among others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone-iodine is as effective and safe as talc, and may be preferred because of its easy availability and low cost.[6]

PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology[7] and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").[8]

PVP is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.[9]

PVP was used as a plasma volume expander for trauma victims after the 1950s. It is not preferred as a volume expander due to its ability to provoke histamine release and also interfere with blood grouping.

Autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[10] The long-term effects of crospovidone or povidone within the lung are unknown.

Technical

PVP is also used in many technical applications:

Other uses

PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[17][18] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.

In in-vitro fertilisation laboratories, polyvinylpyrrolidone is used to slow down spermatozoa in order to capture them for e.g. ICSI.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.[19]

PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.[20]

Safety

The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[21] and it is generally recognized as safe (GRAS). PVP is included in the Inactive Ingredient Database for use in oral, topical, and injectable formulations.

However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes.

Examples of documented allergic reactions:

Additionally, Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses. Yet subsequent testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[25][26]

There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.[27]

Properties

PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,[28] as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).[29] When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.[30]

History

PVP was first synthesized by BASF chemist Walter Reppe, and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.[31][32] BASF continues to make PVP, including a pharmaceutical portfolio under the brand name of Kollidon.[33]

Cross-linked derivatives

Main page: Chemistry:Polyvinylpolypyrrolidone

See also

References

  1. ↑ Haaf, F.; Sanner, A.; Straub, F. (1985). "Polymers of N-Vinylpyrrolidone: Synthesis, Characterization and Uses". Polymer Journal 17: 143–152. doi:10.1295/polymj.17.143. 
  2. ↑ "Povidones, Copovidones, and Crospovidones for Pharmaceutical Products" (in en-US). https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones. 
  3. ↑ Kutscher, Bernhard (2020). "Ullmann's Encyclopedia of Industrial Chemistry". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. pp. 1–22. doi:10.1002/14356007.w08_w03. 
  4. ↑ Bühler, Volker (2005). Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone. Berlin, Heidelberg, New York: Springer. pp. 1–254. doi:10.1007/b138598. ISBN 978-3540234128. https://archive.org/details/polyvinylpyrroli00buhl. 
  5. ↑ PVP-Iodine. ispcorp.com. 2004.
  6. ↑ "A study of comparison of efficacy and safety of talc and povidone iodine for pleurodesis of malignant pleural effusions". Journal of the Indian Medical Association 106 (9): 589–90, 592. 2008. PMID 19552086. 
  7. ↑ "Contact Lens Design & Materials: New Lens Technology Targets Improved Vision and Comfort". May 1, 2014. https://www.clspectrum.com/issues/2014/may-2014/contact-lens-design-amp;-materials. 
  8. ↑ "Contact Lens Design & Materials: The Evolution of Contact Lens Wetting Agents". October 1, 2009. https://www.clspectrum.com/issues/2009/october-2009/contact-lens-materials. 
  9. ↑ "Soothe Hydration Lubricant Eye Drops". Bausch & Lomb. http://www.bausch.com/our-products/dry-eye-products/dry-eye-products/soothe-hydration-lubricant-eye-drops. 
  10. ↑ Ganesan, S; Felo, J; Saldana, M; Kalasinsky, V. F.; Lewin-Smith, M. R.; Tomashefski Jr, J. F. (2003). "Embolized crospovidone (polyN-vinyl-2-pyrrolidone) in the lungs of intravenous drug users". Modern Pathology 16 (4): 286–92. doi:10.1097/01.MP.0000062653.65441.DA. PMID 12692192. 
  11. ↑ Swei, J.; Talbot, J. B. (2006). "Development of high-definition aqueous polyvinylpyrrolidone photoresists for cathode ray tubes". Journal of Applied Polymer Science 102 (2): 1637–1644. doi:10.1002/app.23950. 
  12. ↑ Chen, Tianming "Dental bleach", U.S. Patent 6,730,316, Priority date January 27, 2001
  13. ↑ "Pharmaceutical Povidones, Copovidones, Crospovidones" (in en). https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones?at_medium=display&at_campaign=enp_baw_glob_en_sol_tra_wikipedia&at_creation=landing-page_wikipedia_chemistry-page_basf-wikipedia-article&at_channel=wikipedia&at_format=chemistry-page&at_variant=basf-wikipedia-article. 
  14. ↑ Kavakka, J. S.; KilpeläInen, I.; Heikkinen, S. (2009). "General Chromatographic NMR Method in Liquid State for Synthetic Chemistry: Polyvinylpyrrolidone Assisted DOSY Experiments". Organic Letters 11 (6): 1349–52. doi:10.1021/ol9001398. PMID 19231850. 
  15. ↑ Koczkur, Kallum M.; Mourdikoudis, Stefanos; Polavarapu, Lakshminarayana; Skrabalak, Sara E. (2015). "Polyvinylpyrrolidone (PVP) in nanoparticle synthesis" (in en). Dalton Transactions 44 (41): 17883–17905. doi:10.1039/C5DT02964C. PMID 26434727. https://hal.sorbonne-universite.fr/hal-01217114/file/Koczkur_2015_Polyvinylpyrrolidone.pdf. 
  16. ↑ Li, Bo; Zhang, Yanan; Fu, Lin (2018). "Surface passivation engineering strategy to fully-inorganic cubic CsPbI 3 perovskites for high-performance solar cells". Nature 9 (1): 8. doi:10.1038/s41467-018-03169-0. PMID 29540764. PMC 5852044. Bibcode: 2018NatCo...9.1076L. https://www.nature.com/articles/s41467-018-03169-0.pdf. 
  17. ↑ Fischer, Frank; Bauer, Stephan (2009). "Ein Polyvinylpyrrolidon (PVP): ein vielseitiges Spezialpolymer – Verwendung in der Keramik und als Metallabschreckmedium". Keramische Zeitschrift 61 (6): 382–385. 
  18. ↑ Göthlich, Alexander; Koltzenburg, Sebastian; Schornick, Gunnar (2005). "Funktionale Polymere im Alltag: Vielseitig". Chemie in unserer Zeit 39 (4): 262–273. doi:10.1002/ciuz.200400346. 
  19. ↑ Lillie RD & Fullmer HM (1976) Histopathologic Technic and Practical Histochemistry, 4th ed. New York: McGraw-Hill, p. 411. ISBN:0-07-037862-2.
  20. ↑ Broadhurst, C. Leigh; Polansky, Marilyn M; Anderson, Richard A (March 2, 2000). "Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro". Journal of Agricultural and Food Chemistry 48 (3): 849–52. doi:10.1021/jf9904517. PMID 10725162. 
  21. ↑ Inactive Ingredients in FDA Approved Drugs. FDA/Center for Drug Evaluation and Research, Office of Generic Drugs, Division of Labeling and Program Support. Database Update Frequency: Quarterly. Data Through: January 6, 2010. Database Last Updated: January 13, 2010 – search on povidone for list of approved items
  22. ↑ "Anaphylaxis to polyvinylpyrrolidone in povidone-iodine for impetigo contagiosum in a boy with atopic dermatitis". International Archives of Allergy and Immunology 146 (2): 169–73. 2008. doi:10.1159/000113522. PMID 18204285. 
  23. ↑ "Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine". Contact Dermatitis 48 (3): 133–6. March 2003. doi:10.1034/j.1600-0536.2003.00050.x. PMID 12755725. 
  24. ↑ "Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation". The British Journal of Dermatology 143 (5): 1055–8. November 2000. doi:10.1046/j.1365-2133.2000.03843.x. PMID 11069520. 
  25. ↑ Katelaris, Constance (2009). "'Iodine Allergy' label is misleading". Australian Prescriber 32 (5): 125–128. doi:10.18773/austprescr.2009.061. 
  26. ↑ "Sensitization to povidone-iodine". Dermatologic Clinics 8 (1): 107–9. January 1990. doi:10.1016/S0733-8635(18)30531-X. PMID 2302848. 
  27. ↑ "Povidones, Copovidones, and Crospovidones for Pharmaceutical Products" (in en-US). https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones. 
  28. ↑ Wohlfarth, C (2010). "Thermodynamic Properties of Polymer Solutions.". Landolt-Börnstein, New Series, Group VIII, Volume 6D. Landolt-Börnstein - Group VIII Advanced Materials and Technologies. 6D2. Springer Verlag. pp. 1266–1267. doi:10.1007/978-3-642-02890-8_752. ISBN 978-3-642-02889-2. Bibcode: 2010LanB..6D2.1266W. 
  29. ↑ Sapir, L.; Stanley, CB.; Harries, D. (2016). "Properties of Polyvinylpyrrolidone in a Deep Eutectic Solvent". J. Phys. Chem. A 120 (19): 3253–3259. doi:10.1021/acs.jpca.5b11927. PMID 26963367. Bibcode: 2016JPCA..120.3253S. 
  30. ↑ Song, Guoshan; Lin, Yannan; Zhu, Zhongcheng; Zheng, Heying; Qiao, Jinping; He, Changcheng; Wang, Huiliang (2015). "Strong Fluorescence of Poly(N-vinylpyrrolidone) and Its Oxidized Hydrolyzate". Macromolecular Rapid Communications 36 (3): 278–85. doi:10.1002/marc.201400516. PMID 25420749. 
  31. ↑ Fischer, Frank; Bauer, Stephan (2009). "Polyvinylpyrrolidon. Ein Tausendsassa in der Chemie". Chemie in unserer Zeit 43 (6): 376–383. doi:10.1002/ciuz.200900492. 
  32. ↑ Koczkur, Kallum M.; Mourdikoudis, Stefanos; Polavarapu, Lakshminarayana; Skrabalak, Sara E. (2015). "Polyvinylpyrrolidone (PVP) in nanoparticle synthesis" (in en). Dalton Transactions 44 (41): 17883–17905. doi:10.1039/C5DT02964C. PMID 26434727. https://hal.sorbonne-universite.fr/hal-01217114/file/Koczkur_2015_Polyvinylpyrrolidone.pdf. 
  33. ↑ "Povidones, Copovidones, and Crospovidones for Pharmaceutical Products" (in en-US). https://pharma.basf.com/chemistry/povidones-copovidones-crospovidones. 



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