Chemistry:CyRL-QN15

From HandWiki

CyRL-QN15 is a cyclic heptapeptide derivative with the sequence -CQFHYMC-, linked by a disulphide bond between the two cysteine residues. It was derived from peptides found in the skin secretions of the frog Rana limnocharis.[1][2] It enhances wound healing and has been researched for the treatment of diabetic ulcers. It has several different mechanisms of action, including acting as an antagonist at TLR4 and indirectly activating SIRT1.[3][4][5][6][7][8][9][10]

See also

References

  1. ↑ "Discovery of a novel short peptide with efficacy in accelerating the healing of skin wounds". Pharmacological Research 163. January 2021. doi:10.1016/j.phrs.2020.105296. PMID 33220421. 
  2. ↑ "Characterization and mechanism of action of amphibian-derived wound-healing-promoting peptides". Frontiers in Cell and Developmental Biology 11. 2023. doi:10.3389/fcell.2023.1219427. PMID 37397255. 
  3. ↑ "Discovery of bioactive peptides as therapeutic agents for skin wound repair". Journal of Tissue Engineering 15. 2024. doi:10.1177/20417314241280359. PMID 39398382. 
  4. ↑ "Peptide Cy RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor". Zoological Research 45 (6): 1287–1299. November 2024. doi:10.24272/j.issn.2095-8137.2024.134. PMID 39479995. 
  5. ↑ "Hydrogel Loaded with Peptide-Containing Nanocomplexes: Symphonic Cooperation of Photothermal Antimicrobial Nanoparticles and Prohealing Peptides for the Treatment of Infected Wounds". ACS Applied Materials & Interfaces 16 (11): 13422–13438. March 2024. doi:10.1021/acsami.3c16061. PMID 38442213. Bibcode: 2024AAMI...1613422J. 
  6. ↑ "Inhibition of miRNA-365-2-5p Targeting SIRT1 Regulates Functions of Keratinocytes to Enhance Wound Healing". FASEB Journal 39 (8). April 2025. doi:10.1096/fj.202401124RRR. PMID 40261275. 
  7. ↑ "Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis". Journal of Medicinal Chemistry 68 (18): 19503–19520. September 2025. doi:10.1021/acs.jmedchem.5c01734. PMID 40910702. 
  8. ↑ "Peptide CyRL-QN15 alleviates UVB-induced skin aging by promoting the repair of barrier". Ecotoxicology and Environmental Safety 300. July 2025. doi:10.1016/j.ecoenv.2025.118465. PMID 40472691. 
  9. ↑ "Ultra-short cyclic peptide Cy RL-QN15 acts as a TLR4 antagonist to expedite oral ulcer healing". Zoological Research 46 (5): 1187–1202. September 2025. doi:10.24272/j.issn.2095-8137.2025.211. PMID 41017403. 
  10. ↑ "MiR-181d-5p affects skin wound healing processes via the Ikbkg/NF-κB axis". International Journal of Biological Macromolecules 322 (Pt 4). September 2025. doi:10.1016/j.ijbiomac.2025.147007. PMID 40840735. 



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